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Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span
The shelterin complex protects telomeres by preventing them from being degraded and recognized as double‐strand DNA breaks. TRF1 is an essential component of shelterin, with important roles in telomere protection and telomere replication. We previously showed that TRF1 deficiency in the context of d...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676056/ https://www.ncbi.nlm.nih.gov/pubmed/28944611 http://dx.doi.org/10.1111/acel.12677 |