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Hyperphosphatemia induces senescence in human endothelial cells by increasing endothelin‐1 production

Hyperphosphatemia is related to some pathologies, affecting vascular cell behavior. This work analyzes whether high concentration of extracellular phosphate induces endothelial senescence through up‐regulation of endothelin‐1 (ET‐1), exploring the mechanisms involved. The phosphate donor β‐glyceroph...

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Detalles Bibliográficos
Autores principales: Olmos, Gemma, Martínez‐Miguel, Patricia, Alcalde‐Estevez, Elena, Medrano, Diana, Sosa, Patricia, Rodríguez‐Mañas, Leocadio, Naves‐Diaz, Manuel, Rodríguez‐Puyol, Diego, Ruiz‐Torres, María Piedad, López‐Ongil, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676064/
https://www.ncbi.nlm.nih.gov/pubmed/28857396
http://dx.doi.org/10.1111/acel.12664