Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity

Griselimycins (GMs) are depsidecapeptides with superb anti-tuberculosis activity. They contain up to three (2S,4R)-4-methyl-prolines (4-MePro), of which one blocks oxidative degradation and increases metabolic stability in animal models. The natural congener with this substitution is only a minor co...

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Detalles Bibliográficos
Autores principales: Lukat, Peer, Katsuyama, Yohei, Wenzel, Silke, Binz, Tina, König, Claudia, Blankenfeldt, Wulf, Brönstrup, Mark, Müller, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676206/
https://www.ncbi.nlm.nih.gov/pubmed/29163906
http://dx.doi.org/10.1039/c7sc02622f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676206/
https://www.ncbi.nlm.nih.gov/pubmed/29163906
http://dx.doi.org/10.1039/c7sc02622f

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