Cargando…
Will Big Data Close the Missing Heritability Gap?
Despite the important discoveries reported by genome-wide association (GWA) studies, for most traits and diseases the prediction R-squared (R-sq.) achieved with genetic scores remains considerably lower than the trait heritability. Modern biobanks will soon deliver unprecedentedly large biomedical d...
Autores principales: | Kim, Hwasoon, Grueneberg, Alexander, Vazquez, Ana I., Hsu, Stephen, de los Campos, Gustavo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Genetics Society of America
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676235/ https://www.ncbi.nlm.nih.gov/pubmed/28893854 http://dx.doi.org/10.1534/genetics.117.300271 |
Ejemplares similares
-
BGData - A Suite of R Packages for Genomic Analysis with Big Data
por: Grueneberg, Alexander, et al.
Publicado: (2019) -
Beyond Missing Heritability: Prediction of Complex Traits
por: Makowsky, Robert, et al.
Publicado: (2011) -
Imperfect Linkage Disequilibrium Generates Phantom Epistasis (& Perils of Big Data)
por: de los Campos, Gustavo, et al.
Publicado: (2019) -
Targeted Gene Sequencing in Children with Crohn’s Disease and Their Parents: Implications for Missing Heritability
por: Chen, Jiun-Sheng, et al.
Publicado: (2018) -
Closing Human Reference Genome Gaps: Identifying and Characterizing Gap-Closing Sequences
por: Zhao, Tingting, et al.
Publicado: (2020)