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Will Big Data Close the Missing Heritability Gap?

Despite the important discoveries reported by genome-wide association (GWA) studies, for most traits and diseases the prediction R-squared (R-sq.) achieved with genetic scores remains considerably lower than the trait heritability. Modern biobanks will soon deliver unprecedentedly large biomedical d...

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Detalles Bibliográficos
Autores principales: Kim, Hwasoon, Grueneberg, Alexander, Vazquez, Ana I., Hsu, Stephen, de los Campos, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676235/
https://www.ncbi.nlm.nih.gov/pubmed/28893854
http://dx.doi.org/10.1534/genetics.117.300271