Sirt1 Protects Endothelial Cells against LPS-Induced Barrier Dysfunction

Sepsis is a threatening health problem and characterized by microvascular dysfunction. In this study, we verified that LPS caused the downregulation of Sirt1 and the hyperpermeability of endothelial cells. Inhibition of Sirt1 with ex527 or Sirt1 siRNA displayed a higher permeability, while activatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Weijin, Zhang, Yaoyuan, Guo, Xiaohua, Zeng, Zhenhua, Wu, Jie, Liu, Yanan, He, Jing, Wang, Ruiting, Huang, Qiaobing, Chen, Zhongqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676476/
https://www.ncbi.nlm.nih.gov/pubmed/29209448
http://dx.doi.org/10.1155/2017/4082102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676476/
https://www.ncbi.nlm.nih.gov/pubmed/29209448
http://dx.doi.org/10.1155/2017/4082102

Ejemplares similares