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Sirt1 Protects Endothelial Cells against LPS-Induced Barrier Dysfunction
Sepsis is a threatening health problem and characterized by microvascular dysfunction. In this study, we verified that LPS caused the downregulation of Sirt1 and the hyperpermeability of endothelial cells. Inhibition of Sirt1 with ex527 or Sirt1 siRNA displayed a higher permeability, while activatio...
Autores principales: | Zhang, Weijin, Zhang, Yaoyuan, Guo, Xiaohua, Zeng, Zhenhua, Wu, Jie, Liu, Yanan, He, Jing, Wang, Ruiting, Huang, Qiaobing, Chen, Zhongqing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676476/ https://www.ncbi.nlm.nih.gov/pubmed/29209448 http://dx.doi.org/10.1155/2017/4082102 |
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