A simplified characterization of S-adenosyl-l-methionine-consuming enzymes with 1-Step EZ-MTase: a universal and straightforward coupled-assay for in vitro and in vivo setting

Methyltransferases use S-adenosyl-l-methionine (SAM) to deposit methyl marks. Many of these epigenetic ‘writers’ are associated with gene regulation. As cancer etiology is highly correlated with misregulated methylation patterns, methyltransferases are emerging therapeutic targets. Successful assign...

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Detalles Bibliográficos
Autores principales: Burgos, Emmanuel S., Walters, Ryan O., Huffman, Derek M., Shechter, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676521/
https://www.ncbi.nlm.nih.gov/pubmed/29449933
http://dx.doi.org/10.1039/c7sc02830j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676521/
https://www.ncbi.nlm.nih.gov/pubmed/29449933
http://dx.doi.org/10.1039/c7sc02830j

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