Crystal structures of trimeric HIV Env with entry inhibitors BMS-378806 and BMS-626529

The HIV-1-envelope (Env) spike is a conformational machine that transitions between prefusion (closed, CD4-bound, CCR5-bound) and postfusion states to facilitate HIV-1 entry. Although the prefusion-closed conformation is a potential target for inhibition, development of small molecule leads has been...

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Detalles Bibliográficos
Autores principales: Pancera, Marie, Lai, Yen-Ting, Bylund, Tatsiana, Druz, Aliaksandr, Narpala, Sandeep, O’Dell, Sijy, Schön, Arne, Bailer, Robert T., Chuang, Gwo-Yu, Geng, Hui, Louder, Mark K., Rawi, Reda, Soumana, Djade I., Finzi, Andrés, Herschhorn, Alon, Madani, Navid, Sodroski, Joseph, Freire, Ernesto, Langley, David R., Mascola, John R., McDermott, Adrian B., Kwong, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676566/
https://www.ncbi.nlm.nih.gov/pubmed/28825711
http://dx.doi.org/10.1038/nchembio.2460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676566/
https://www.ncbi.nlm.nih.gov/pubmed/28825711
http://dx.doi.org/10.1038/nchembio.2460

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