Activation of G-protein-gated inwardly rectifying potassium (Kir3/GirK) channels rescues hippocampal functions in a mouse model of early amyloid-β pathology

The hippocampus plays a critical role in learning and memory. Its correct performance relies on excitatory/inhibitory synaptic transmission balance. In early stages of Alzheimer’s disease (AD), neuronal hyperexcitability leads to network dysfunction observed in cortical regions such as the hippocamp...

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Detalles Bibliográficos
Autores principales: Sánchez-Rodríguez, Irene, Temprano-Carazo, Sara, Nájera, Alberto, Djebari, Souhail, Yajeya, Javier, Gruart, Agnès, Delgado-García, José M., Jiménez-Díaz, Lydia, Navarro-López, Juan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676742/
https://www.ncbi.nlm.nih.gov/pubmed/29116174
http://dx.doi.org/10.1038/s41598-017-15306-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676742/
https://www.ncbi.nlm.nih.gov/pubmed/29116174
http://dx.doi.org/10.1038/s41598-017-15306-8

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