Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis

Peripheral serotonin (5-hydroxytryptamine, 5-HT) regulates cell growth and differentiation in numerous cell types through engagement of seven types of cell surface receptors (HTR1–7). Deregulated 5-HT/HTR levels contribute to pathology in chronic inflammatory diseases, with macrophages being relevan...

Descripción completa

Detalles Bibliográficos
Autores principales: Domínguez-Soto, Ángeles, Usategui, Alicia, Casas-Engel, Mateo de las, Simón-Fuentes, Miriam, Nieto, Concha, Cuevas, Víctor D., Vega, Miguel A., Luis Pablos, José, Corbí, Ángel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676747/
https://www.ncbi.nlm.nih.gov/pubmed/29116249
http://dx.doi.org/10.1038/s41598-017-15348-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676747/
https://www.ncbi.nlm.nih.gov/pubmed/29116249
http://dx.doi.org/10.1038/s41598-017-15348-y

Ejemplares similares