Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor Neurons

In vitro generation of motor neurons (MNs) is a promising approach for modeling motor neuron diseases (MNDs) such as amyotrophic lateral sclerosis (ALS). As aging is a leading risk factor for the development of neurodegeneration, it is important to recapitulate age-related characteristics by using M...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Yu, Liu, Meng-Lu, Zang, Tong, Zhang, Chun-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676779/
https://www.ncbi.nlm.nih.gov/pubmed/29163034
http://dx.doi.org/10.3389/fnmol.2017.00359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676779/
https://www.ncbi.nlm.nih.gov/pubmed/29163034
http://dx.doi.org/10.3389/fnmol.2017.00359

Ejemplares similares