Resistance to TGFβ suppression and improved anti-tumor responses in CD8(+) T cells lacking PTPN22

Transforming growth factor β (TGFβ) is important in maintaining self-tolerance and inhibits T cell reactivity. We show that CD8(+) T cells that lack the tyrosine phosphatase Ptpn22, a major predisposing gene for autoimmune disease, are resistant to the suppressive effects of TGFβ. Resistance to TGFβ...

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Detalles Bibliográficos
Autores principales: Brownlie, Rebecca J., Garcia, Celine, Ravasz, Mate, Zehn, Dietmar, Salmond, Robert J., Zamoyska, Rose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676842/
https://www.ncbi.nlm.nih.gov/pubmed/29116089
http://dx.doi.org/10.1038/s41467-017-01427-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676842/
https://www.ncbi.nlm.nih.gov/pubmed/29116089
http://dx.doi.org/10.1038/s41467-017-01427-1

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