In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase

T cell signaling initiates upon the binding of peptide-loaded MHC (pMHC) on an antigen-presenting cell to the T cell receptor (TCR) on a T cell. TCR phosphorylation in response to pMHC binding is accompanied by segregation of the transmembrane phosphatase CD45 away from TCR–pMHC complexes. The kinet...

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Detalles Bibliográficos
Autores principales: Carbone, Catherine B., Kern, Nadja, Fernandes, Ricardo A., Hui, Enfu, Su, Xiaolei, Garcia, K. Christopher, Vale, Ronald D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2017
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676914/
https://www.ncbi.nlm.nih.gov/pubmed/29042512
http://dx.doi.org/10.1073/pnas.1710358114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676914/
https://www.ncbi.nlm.nih.gov/pubmed/29042512
http://dx.doi.org/10.1073/pnas.1710358114

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