Inactivation mechanism of N61S mutant of human FMO3 towards trimethylamine

Human flavin-containing monooxygenase 3 (hFMO3) catalyses the oxygenation of a wide variety of compounds including drugs as well as dietary compounds. It is the major hepatic enzyme involved in the production of the N-oxide of trimethylamine (TMAO) and clinical studies have uncovered a striking corr...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Chongliang, Catucci, Gianluca, Castrignanò, Silvia, Gilardi, Gianfranco, Sadeghi, Sheila J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676948/
https://www.ncbi.nlm.nih.gov/pubmed/29116146
http://dx.doi.org/10.1038/s41598-017-15224-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676948/
https://www.ncbi.nlm.nih.gov/pubmed/29116146
http://dx.doi.org/10.1038/s41598-017-15224-9

Ejemplares similares