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Inactivation mechanism of N61S mutant of human FMO3 towards trimethylamine

Human flavin-containing monooxygenase 3 (hFMO3) catalyses the oxygenation of a wide variety of compounds including drugs as well as dietary compounds. It is the major hepatic enzyme involved in the production of the N-oxide of trimethylamine (TMAO) and clinical studies have uncovered a striking corr...

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Detalles Bibliográficos
Autores principales:	Gao, Chongliang, Catucci, Gianluca, Castrignanò, Silvia, Gilardi, Gianfranco, Sadeghi, Sheila J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676948/ https://www.ncbi.nlm.nih.gov/pubmed/29116146 http://dx.doi.org/10.1038/s41598-017-15224-9

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