Cargando…

Inactivation mechanism of N61S mutant of human FMO3 towards trimethylamine

Human flavin-containing monooxygenase 3 (hFMO3) catalyses the oxygenation of a wide variety of compounds including drugs as well as dietary compounds. It is the major hepatic enzyme involved in the production of the N-oxide of trimethylamine (TMAO) and clinical studies have uncovered a striking corr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Chongliang, Catucci, Gianluca, Castrignanò, Silvia, Gilardi, Gianfranco, Sadeghi, Sheila J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676948/ https://www.ncbi.nlm.nih.gov/pubmed/29116146 http://dx.doi.org/10.1038/s41598-017-15224-9

Ejemplares similares

Production of drug metabolites by human FMO3 in Escherichia coli
por: Catucci, Gianluca, et al.
Publicado: (2020)

Human Cytochrome P450 3A4 as a Biocatalyst: Effects of the Engineered Linker in Modulation of Coupling Efficiency in 3A4-BMR Chimeras
por: Degregorio, Danilo, et al.
Publicado: (2017)

Association of FMO3 Variants and Trimethylamine N-Oxide Concentration, Disease Progression, and Mortality in CKD Patients
por: Robinson-Cohen, Cassianne, et al.
Publicado: (2016)

Drug metabolite synthesis by immobilized human FMO3 and whole cell catalysts
por: Gao, Chongliang, et al.
Publicado: (2019)

Molecular Lego of Human Cytochrome P450: The Key Role of Heme Domain Flexibility for the Activity of the Chimeric Proteins
por: Catucci, Gianluca, et al.
Publicado: (2022)

Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease
por: Fennema, Diede, et al.
Publicado: (2016)

Expression of Concern to: Drug metabolite synthesis by immobilized human FMO3 and whole cell catalysts
por: Gao, Chongliang, et al.
Publicado: (2020)

Effect of Human Flavin-Containing Monooxygenase 3 Polymorphism on the Metabolism of Aurora Kinase Inhibitors
por: Catucci, Gianluca, et al.
Publicado: (2013)

Revisiting the optical properties of the FMO protein
por: Milder, Maaike T. W., et al.
Publicado: (2010)

Restored mutant receptor:Corticoid binding in chaperone complexes by trimethylamine N-oxide
por: Miller, Aaron L., et al.
Publicado: (2017)

Dynamics and Flexibility of Human Aromatase Probed by FTIR and Time Resolved Fluorescence Spectroscopy
por: Di Nardo, Giovanna, et al.
Publicado: (2013)

Enhanced and specific epoxidation activity of P450 BM3 mutants for the production of high value terpene derivatives
por: Correddu, Danilo, et al.
Publicado: (2022)

Discovery of the Odderon by TOTEM experiments and the FMO approach
por: Martynov, Evgenij, et al.
Publicado: (2019)

Fluorescence-excitation and Emission Spectroscopy on Single FMO Complexes
por: Löhner, Alexander, et al.
Publicado: (2016)

Loopy Sec61 mutants
por: LeBrasseur, Nicole
Publicado: (2005)

The Cranberry Extract Oximacro(®) Exerts in vitro Virucidal Activity Against Influenza Virus by Interfering With Hemagglutinin
por: Luganini, Anna, et al.
Publicado: (2018)

Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice
por: Kuka, Janis, et al.
Publicado: (2020)

Association of Trimethylamine, Trimethylamine N-oxide, and Dimethylamine with Cardiovascular Risk in Children with Chronic Kidney Disease
por: Hsu, Chien-Ning, et al.
Publicado: (2020)

Discovery and identification of the prognostic significance and potential mechanism of FMO2 in breast cancer
por: Wu, Lichun, et al.
Publicado: (2023)

FMO4 shapes immuno‐metabolic reconfiguration in hepatocellular carcinoma
por: Luo, Yan, et al.
Publicado: (2022)

Simultaneous Measurement of Urinary Trimethylamine (TMA) and Trimethylamine N-Oxide (TMAO) by Liquid Chromatography–Mass Spectrometry
por: Jia, Xun, et al.
Publicado: (2020)

Higher Trimethylamine-N-Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria
por: Rath, Silke, et al.
Publicado: (2021)

Trimethylamine N-Oxide: The Good, the Bad and the Unknown
por: Velasquez, Manuel T., et al.
Publicado: (2016)

Trimethylamine N-oxide in atrial fibrillation progression
por: Büttner, Petra, et al.
Publicado: (2020)

Trimethylamine N-oxide (TMAO) in human health
por: Gatarek, Paulina, et al.
Publicado: (2021)

Influence of Trimethylamine N-Oxide on Platelet Activation
por: Emonds, Julian Josef, et al.
Publicado: (2022)

Association of Urinary and Plasma Levels of Trimethylamine N-Oxide (TMAO) with Foods
por: Lombardo, Mauro, et al.
Publicado: (2021)

Oxidation of trimethylamine to trimethylamine N-oxide facilitates high hydrostatic pressure tolerance in a generalist bacterial lineage
por: Qin, Qi-Long, et al.
Publicado: (2021)

Identification of a novel Baeyer‐Villiger monooxygenase from Acinetobacter radioresistens: close relationship to the Mycobacterium tuberculosis prodrug activator EtaA
por: Minerdi, Daniela, et al.
Publicado: (2012)

Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy
por: Wang, BingYu, et al.
Publicado: (2021)

Association of the Chronotype Score with Circulating Trimethylamine N-Oxide (TMAO) Concentrations
por: Barrea, Luigi, et al.
Publicado: (2021)

Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota
por: Hoyles, Lesley, et al.
Publicado: (2018)

Gut microbiota in atherosclerosis: focus on trimethylamine N‐oxide
por: Zhu, Yingqian, et al.
Publicado: (2020)

Polycentric binding in complexes of trimethylamine-N-oxide with dihalogens
por: Zarechnaya, Olga M., et al.
Publicado: (2021)

Gut microbiota dependant trimethylamine N-oxide and hypertension
por: Mutengo, Katongo H., et al.
Publicado: (2023)

Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome
por: Li, Xingxing, et al.
Publicado: (2021)

Trimethylamine N-Oxide Promotes Cell Proliferation and Angiogenesis in Colorectal Cancer
por: Yang, Shuyan, et al.
Publicado: (2022)

Hybrid QM/MM study of FMO complex with polarized protein-specific charge
por: Jia, Xiangyu, et al.
Publicado: (2015)

Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
por: El-Serafi, Ibrahim, et al.
Publicado: (2017)

Association of FMO3 Variants with Blood Pressure in the Atherosclerosis Risk in Communities Study
por: Bryant, Tyler S., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_sd4gf5bh5var9h1d4or7797im9