Constitutive expression of NF-κB inducing kinase in regulatory T cells impairs suppressive function and promotes instability and pro-inflammatory cytokine production

CD4(+)Foxp3(+) regulatory T cells (Tregs) are indispensable negative regulators of immune responses. To understand Treg biology in health and disease, it is critical to elucidate factors that affect Treg homeostasis and suppressive function. Tregs express several costimulatory TNF receptor family me...

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Detalles Bibliográficos
Autores principales: Polesso, Fanny, Sarker, Minhazur, Anderson, Arian, Parker, David C., Murray, Susan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677020/
https://www.ncbi.nlm.nih.gov/pubmed/29116141
http://dx.doi.org/10.1038/s41598-017-14965-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677020/
https://www.ncbi.nlm.nih.gov/pubmed/29116141
http://dx.doi.org/10.1038/s41598-017-14965-x

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