Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D)

Fragile-X syndrome (FXS) patients display intellectual disability and autism spectrum disorder due to silencing of the X-linked, fragile-X mental retardation-1 (FMR1) gene. Dysregulation of cAMP metabolism is a consistent finding in patients and in the mouse and fly FXS models. We therefore explored...

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Detalles Bibliográficos
Autores principales: Gurney, Mark E., Cogram, Patricia, Deacon, Robert M, Rex, Christopher, Tranfaglia, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677090/
https://www.ncbi.nlm.nih.gov/pubmed/29116166
http://dx.doi.org/10.1038/s41598-017-15028-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677090/
https://www.ncbi.nlm.nih.gov/pubmed/29116166
http://dx.doi.org/10.1038/s41598-017-15028-x

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