Using CRISPR-Cas9-mediated genome editing to generate C. difficile mutants defective in selenoproteins synthesis

Clostridium difficile is a significant concern as a nosocomial pathogen, and genetic tools are important when analyzing the physiology of such organisms so that the underlying physiology/pathogenesis of the organisms can be studied. Here, we used TargeTron to investigate the role of selenoproteins i...

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Detalles Bibliográficos
Autores principales: McAllister, Kathleen N., Bouillaut, Laurent, Kahn, Jennifer N., Self, William T., Sorg, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677094/
https://www.ncbi.nlm.nih.gov/pubmed/29116155
http://dx.doi.org/10.1038/s41598-017-15236-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677094/
https://www.ncbi.nlm.nih.gov/pubmed/29116155
http://dx.doi.org/10.1038/s41598-017-15236-5

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