Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2

Epigenetic processes have been implicated in the pathophysiology of alcohol dependence, but the specific molecular mechanisms mediating dependence-induced neuroadaptations remain largely unknown. Here, we found that a history of alcohol dependence persistently decreased the expression of Prdm2, a hi...

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Detalles Bibliográficos
Autores principales: Barbier, E, Johnstone, AL, Khomtchouk, BB, Tapocik, JD, Pitcairn, C, Rehman, F, Augier, E, Borich, A, Schank, JR, Rienas, CA, Van Booven, DJ, Sun, H, Nätt, D, Wahlestedt, C, Heilig, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677579/
https://www.ncbi.nlm.nih.gov/pubmed/27573876
http://dx.doi.org/10.1038/mp.2016.131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677579/
https://www.ncbi.nlm.nih.gov/pubmed/27573876
http://dx.doi.org/10.1038/mp.2016.131

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