Identification of potentially oncogenic alterations from tumor-only samples reveals Fanconi anemia pathway mutations in bladder carcinomas

Cancer is caused by germline and somatic mutations, which can share biological features such as amino acid change. However, integrated germline and somatic analysis remains uncommon. We present a framework that uses machine learning to learn features of recurrent somatic mutations to (1) predict som...

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Detalles Bibliográficos
Autores principales: Madubata, Chioma J, Roshan-Ghias, Alireza, Chu, Timothy, Resnick, Samuel, Zhao, Junfei, Arnes, Luis, Wang, Jiguang, Rabadan, Raul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677944/
https://www.ncbi.nlm.nih.gov/pubmed/29263839
http://dx.doi.org/10.1038/s41525-017-0032-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677944/
https://www.ncbi.nlm.nih.gov/pubmed/29263839
http://dx.doi.org/10.1038/s41525-017-0032-5

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