Engineering DNA Backbone Interactions Results in TALE Scaffolds with Enhanced 5-Methylcytosine Selectivity

Transcription activator-like effectors (TALEs) are DNA major-groove binding proteins widely used for genome targeting. TALEs contain an N-terminal region (NTR) and a central repeat domain (CRD). Repeats of the CRD selectively recognize each one DNA nucleobase, offering programmability. Moreover, rep...

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Detalles Bibliográficos
Autores principales: Rathi, Preeti, Witte, Anna, Summerer, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678105/
https://www.ncbi.nlm.nih.gov/pubmed/29118409
http://dx.doi.org/10.1038/s41598-017-15361-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678105/
https://www.ncbi.nlm.nih.gov/pubmed/29118409
http://dx.doi.org/10.1038/s41598-017-15361-1

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