A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance

Physiological insulin secretion exhibits various temporal patterns, the dysregulation of which is involved in diabetes development. We analyzed the impact of first-phase and pulsatile insulin release on glucose and lipid control with various hepatic insulin signaling networks. The mathematical model...

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Detalles Bibliográficos
Autores principales: Zhao, Gang, Wirth, Dagmar, Schmitz, Ingo, Meyer-Hermann, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678123/
https://www.ncbi.nlm.nih.gov/pubmed/29118381
http://dx.doi.org/10.1038/s41467-017-01627-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678123/
https://www.ncbi.nlm.nih.gov/pubmed/29118381
http://dx.doi.org/10.1038/s41467-017-01627-9

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