Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance

With the continued emergence of risk loci from Genome-Wide Association studies and variants of uncertain significance identified from patient sequencing, better methods are required to translate these human genetic findings into improvements in public health. Here we combine CRISPR/Cas9 gene editing...

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Detalles Bibliográficos
Autores principales: Coggins, Nicole B., Stultz, Jacob, O’Geen, Henriette, Carvajal-Carmona, Luis G., Segal, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678142/
https://www.ncbi.nlm.nih.gov/pubmed/29118424
http://dx.doi.org/10.1038/s41598-017-15407-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678142/
https://www.ncbi.nlm.nih.gov/pubmed/29118424
http://dx.doi.org/10.1038/s41598-017-15407-4

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