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Mechanotransduction of matrix stiffness in regulation of focal adhesion size and number: reciprocal regulation of caveolin-1 and β1 integrin

Focal adhesion (FA) assembly, mediated by integrin activation, responds to matrix stiffness; however, the underlying mechanisms are unclear. Here, we showed that β1 integrin and caveolin-1 (Cav1) levels were decreased with declining matrix stiffness. Soft matrix selectively downregulated β1 integrin...

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Detalles Bibliográficos
Autores principales: Yeh, Yi-Chun, Ling, Jin-Ying, Chen, Wan-Chun, Lin, Hsi-Hui, Tang, Ming-Jer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678369/
https://www.ncbi.nlm.nih.gov/pubmed/29118431
http://dx.doi.org/10.1038/s41598-017-14932-6