Tet-On lentiviral transductants lose inducibility when silenced for extended intervals in mammary epithelial cells

Silencing of virally transduced genes by promoter methylation and histone deacetylation has been a chronic problem both experimentally and therapeutically. We observed frequent silencing of the tetracycline-inducible Tet-On promoter borne by the Tripz lentivirus in mammary epithelial cell lines. We...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Yang, Lowy, Michelle Montag, Elble, Randolph C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678824/
https://www.ncbi.nlm.nih.gov/pubmed/29142821
http://dx.doi.org/10.1016/j.meteno.2016.03.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678824/
https://www.ncbi.nlm.nih.gov/pubmed/29142821
http://dx.doi.org/10.1016/j.meteno.2016.03.001

Ejemplares similares