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Tet-On lentiviral transductants lose inducibility when silenced for extended intervals in mammary epithelial cells

Silencing of virally transduced genes by promoter methylation and histone deacetylation has been a chronic problem both experimentally and therapeutically. We observed frequent silencing of the tetracycline-inducible Tet-On promoter borne by the Tripz lentivirus in mammary epithelial cell lines. We...

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Detalles Bibliográficos
Autores principales:	Yu, Yang, Lowy, Michelle Montag, Elble, Randolph C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678824/ https://www.ncbi.nlm.nih.gov/pubmed/29142821 http://dx.doi.org/10.1016/j.meteno.2016.03.001

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