The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue

Chemokine CXCL12 gradients drive chemotaxis in a CXCR4-dependent mechanism and have been implicated in cancer metastasis. While CXCL12 gradients are typically studied in organized, defined environments, the tumor microenvironment is disorganized. In vivo, CXCL12 gradients depend on many factors: the...

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Detalles Bibliográficos
Autores principales: Spinosa, Phillip C., Luker, Kathryn E., Luker, Gary D., Linderman, Jennifer J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678865/
https://www.ncbi.nlm.nih.gov/pubmed/29117251
http://dx.doi.org/10.1371/journal.pone.0187357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678865/
https://www.ncbi.nlm.nih.gov/pubmed/29117251
http://dx.doi.org/10.1371/journal.pone.0187357

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