Severe neonatal hyperbilirubinemia in Crigler‐Najjar syndrome model mice can be reversed with zinc protoporphyrin

Neurotoxic bilirubin is solely conjugated by UDP‐glucuronosyltransferase (UGT) 1A1. Due to an inadequate function of UGT1A1, human neonates develop mild to severe physiological hyperbilirubinemia. Accumulation of bilirubin in the brain leads to the onset of irreversible brain damage called kernicter...

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Detalles Bibliográficos
Autores principales: Fujiwara, Ryoichi, Mitsugi, Ryo, Uemura, Asuka, Itoh, Tomoo, Tukey, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678921/
https://www.ncbi.nlm.nih.gov/pubmed/29399656
http://dx.doi.org/10.1002/hep4.1082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678921/
https://www.ncbi.nlm.nih.gov/pubmed/29399656
http://dx.doi.org/10.1002/hep4.1082

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