Two amino acid mutation disrupts RORγt function in Th17 differentiation but not thymocyte development

RORγt regulates T(H)17 differentiation, thymic T cell development and lymph node genesis. Although elimination of RORγt prevents T(H)17-mediated experimental autoimmune encephalomyelitis (EAE), it also disrupts thymocyte development, which could lead to lethal thymic lymphoma. Here we identified two...

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Detalles Bibliográficos
Autores principales: He, Zhiheng, Ma, Jian, Wang, Ruiqing, Zhang, Jing, Huang, Zhaofeng, Wang, Fei, Sen, Subha, Rothenberg, Ellen V., Sun, Zuoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678981/
https://www.ncbi.nlm.nih.gov/pubmed/28846085
http://dx.doi.org/10.1038/ni.3832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678981/
https://www.ncbi.nlm.nih.gov/pubmed/28846085
http://dx.doi.org/10.1038/ni.3832

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