Cargando…

Two amino acid mutation disrupts RORγt function in Th17 differentiation but not thymocyte development

RORγt regulates T(H)17 differentiation, thymic T cell development and lymph node genesis. Although elimination of RORγt prevents T(H)17-mediated experimental autoimmune encephalomyelitis (EAE), it also disrupts thymocyte development, which could lead to lethal thymic lymphoma. Here we identified two...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Zhiheng, Ma, Jian, Wang, Ruiqing, Zhang, Jing, Huang, Zhaofeng, Wang, Fei, Sen, Subha, Rothenberg, Ellen V., Sun, Zuoming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678981/ https://www.ncbi.nlm.nih.gov/pubmed/28846085 http://dx.doi.org/10.1038/ni.3832

Ejemplares similares

Sumoylation of RORγt regulates T(H)17 differentiation and thymocyte development
por: He, Zhiheng, et al.
Publicado: (2018)

Decoupling the role of RORγt in the differentiation and effector function of T(H)17 cells
por: Zhong, Xiancai, et al.
Publicado: (2022)

The Th17 immune response is controlled by the Rel–RORγ–RORγT transcriptional axis
por: Ruan, Qingguo, et al.
Publicado: (2011)

Inhibition of RORγt activity and Th17 differentiation by a set of novel compounds
por: Ding, Qingfeng, et al.
Publicado: (2015)

RORγt and RORα signature genes in human Th17 cells
por: Castro, Glenda, et al.
Publicado: (2017)

Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell Differentiation
por: Ding, Qingfeng, et al.
Publicado: (2015)

Expression of Th-17 and RORγt mRNA in Behçet’s Disease
por: Hamzaoui, Kamel, et al.
Publicado: (2011)

SIRT1 deacetylates RORγt and enhances Th17 cell generation
por: Lim, Hyung W., et al.
Publicado: (2015)

SIRT1 deacetylates RORγt and enhances Th17 cell generation
por: Lim, Hyung W., et al.
Publicado: (2015)

Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases
por: Zeng, Jiuping, et al.
Publicado: (2023)

Transcription of RORγt in Developing Th17 Cells is Regulated by E-Proteins
por: Zhang, Fuping, et al.
Publicado: (2013)

Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology
por: Brucklacher-Waldert, Verena, et al.
Publicado: (2016)

RORγt(+) Treg to Th17 ratios correlate with susceptibility to Giardia infection
por: Yordanova, Ivet A., et al.
Publicado: (2019)

Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo
por: Guendisch, Ulf, et al.
Publicado: (2017)

Digoxin, an Overlooked Agonist of RORγ/RORγT
por: Karaś, Kaja, et al.
Publicado: (2019)

RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation
por: Singh, Amir Kumar, et al.
Publicado: (2023)

Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation
por: Tan, Jun, et al.
Publicado: (2020)

Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis
por: Yang, Wen-Lan, et al.
Publicado: (2023)

IL-23 Promotes TCR-mediated Negative Selection of Thymocytes through the Upregulation of IL-23 Receptor and RORγt
por: Li, Hao, et al.
Publicado: (2014)

Thy-1 (CD90) Signaling Preferentially Promotes RORγt Expression and a Th17 Response
por: Furlong, Suzanne, et al.
Publicado: (2018)

The immunomodulatory effects of TNF-α inhibitors on human Th17 cells via RORγt histone acetylation
por: Lin, Yi-Ching, et al.
Publicado: (2016)

lncRNA STAT4-AS1 Inhibited TH17 Cell Differentiation by Targeting RORγt Protein
por: He, Hanlin, et al.
Publicado: (2022)

The Dichotomous Nature of AZ5104 (an EGFR Inhibitor) Towards RORγ and RORγT
por: Karaś, Kaja, et al.
Publicado: (2019)

IL-7 Receptor Signals Inhibit Expression of Transcription Factors TCF-1, LEF-1, and RORγt: Impact on Thymocyte Development
por: Yu, Qing, et al.
Publicado: (2004)

Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo
por: Saenz, Steven A., et al.
Publicado: (2021)

The application of machine learning methods to the prediction of novel ligands for RORγ/RORγT receptors
por: Bachorz, Rafał A., et al.
Publicado: (2023)

SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation
por: Tian, Yi, et al.
Publicado: (2021)

T-bet represses collagen-induced arthritis by suppressing Th17 lineage commitment through inhibition of RORγt expression and function
por: Shimizu, Masaru, et al.
Publicado: (2021)

Mesenchymal stem cell-derived extracellular vesicles subvert Th17 cells by destabilizing RORγt through posttranslational modification
por: Jung, Sunyoung, et al.
Publicado: (2023)

RORγt inhibitor SR1001 alleviates acute pancreatitis by suppressing pancreatic IL‐17‐producing Th17 and γδ‐T cells in mice with ceruletide‐induced pancreatitis
por: Wang, Jianfa, et al.
Publicado: (2021)

SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2
por: Singh, Amir Kumar, et al.
Publicado: (2018)

The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1
por: Thapa, Puspa, et al.
Publicado: (2017)

RORα and RORγ expression inversely correlates with human melanoma progression
por: Brożyna, Anna A., et al.
Publicado: (2016)

RORγ Structural Plasticity and Druggability
por: Huang, Mian, et al.
Publicado: (2020)

Defined microbiota transplant restores Th17/RORγt(+) regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas
por: Britton, Graham J., et al.
Publicado: (2020)

Transcriptional Interactomic Inhibition of RORα Suppresses Th17-Related Inflammation
por: Ho, Chun-Chang, et al.
Publicado: (2021)

AIM2 promotes T(H)17 cells differentiation by regulating RORγt transcription activity
por: Leite, Jefferson Antônio, et al.
Publicado: (2023)

Silencing RORγt in Human CD4(+) T cells with CD30 aptamer-RORγt shRNA Chimera
por: Shi, Xiaofei, et al.
Publicado: (2019)

Ursolic acid inhibits Th17 cell differentiation via STAT3/RORγt pathway and suppresses Schwann cell-mediated Th17 cell migration by reducing CXCL9/10 expression
por: Xu, Hua, et al.
Publicado: (2022)

Developing and Activated T Cell Survival Depends on Differential Signaling Pathways to Regulate Anti-Apoptotic Bcl-x(L)
por: Wang, Ruiqing, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_nqiaonsc4ngtet68qhkhbtm42u