PML is a ROS sensor activating p53 upon oxidative stress

Promyelocytic leukemia (PML) nuclear bodies (NBs) recruit partner proteins, including p53 and its regulators, thereby controlling their abundance or function. Investigating arsenic sensitivity of acute promyelocytic leukemia, we proposed that PML oxidation promotes NB biogenesis. However, physiologi...

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Detalles Bibliográficos
Autores principales: Niwa-Kawakita, Michiko, Ferhi, Omar, Soilihi, Hassane, Le Bras, Morgane, Lallemand-Breitenbach, Valérie, de Thé, Hugues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679165/
https://www.ncbi.nlm.nih.gov/pubmed/28931625
http://dx.doi.org/10.1084/jem.20160301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679165/
https://www.ncbi.nlm.nih.gov/pubmed/28931625
http://dx.doi.org/10.1084/jem.20160301

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