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Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity
For thymic selection and responses to pathogens, T cells interact through their αβ T cell receptor (TCR) with peptide–major histocompatibility complex (MHC) molecules on antigen-presenting cells. How the diverse TCRs interact with a multitude of MHC molecules is unresolved. It is also unclear how hu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679170/ https://www.ncbi.nlm.nih.gov/pubmed/28835417 http://dx.doi.org/10.1084/jem.20161784 |