Cargando…

STING-associated vasculopathy develops independently of IRF3 in mice

Patients with stimulator of interferon genes (STING)–associated vasculopathy with onset in infancy (SAVI) develop systemic inflammation characterized by vasculopathy, interstitial lung disease, ulcerative skin lesions, and premature death. Autosomal dominant mutations in STING are thought to trigger...

Descripción completa

Detalles Bibliográficos
Autores principales:	Warner, James D., Irizarry-Caro, Ricardo A., Bennion, Brock G., Ai, Teresa L., Smith, Amber M., Miner, Cathrine A., Sakai, Tomomi, Gonugunta, Vijay K., Wu, Jianjun, Platt, Derek J., Yan, Nan, Miner, Jonathan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679177/ https://www.ncbi.nlm.nih.gov/pubmed/28951494 http://dx.doi.org/10.1084/jem.20171351

Ejemplares similares

Transferrable protection by gut microbes against STING-associated lung disease
por: Platt, Derek J., et al.
Publicado: (2021)

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death
por: Wu, Jianjun, et al.
Publicado: (2019)

Regulation of cGAS and STING signaling during inflammation and infection
por: Chauvin, Samuel D., et al.
Publicado: (2023)

The IFN-γ receptor promotes immune dysregulation and disease in STING gain-of-function mice
por: Stinson, W. Alexander, et al.
Publicado: (2022)

Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes
por: Luo, Wei-Wei, et al.
Publicado: (2022)

Lung Inflammation in STING-Associated Vasculopathy with Onset in Infancy (SAVI)
por: David, Clémence, et al.
Publicado: (2022)

Activation of the STING‐IRF3 pathway involved in psoriasis with diabetes mellitus
por: Xiaohong, Li, et al.
Publicado: (2022)

A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI)
por: Lin, Bin, et al.
Publicado: (2020)

PRV UL13 inhibits cGAS–STING-mediated IFN-β production by phosphorylating IRF3
por: Bo, Zongyi, et al.
Publicado: (2020)

An essential and NSF independent role for α-SNAP in store-operated calcium entry
por: Miao, Yong, et al.
Publicado: (2013)

STING-associated vasculopathy with onset in infancy: new clinical findings and mutation in three Turkish children
por: Eroglu, F Kara, et al.
Publicado: (2015)

A Mutation Outside the Dimerization Domain Causing Atypical STING-Associated Vasculopathy With Onset in Infancy
por: Saldanha, Rohit G., et al.
Publicado: (2018)

STING-associated vasculopathy with onset in infancy: a familial case series report and literature review
por: Wang, Yan, et al.
Publicado: (2021)

Use of Tofacitinib for infant-onset STING-associated vasculopathy: A case report from China
por: Shen, Danping, et al.
Publicado: (2022)

Human induced pluripotent stem cells generated from STING-associated vasculopathy with onset in infancy (SAVI) patients with a heterozygous mutation in the STING gene
por: Mehta, Atul, et al.
Publicado: (2022)

The STING/TBK1/IRF3/IFN type I pathway is defective in cystic fibrosis
por: Occhigrossi, Luca, et al.
Publicado: (2023)

IRF4-Dependent and IRF4-Independent Pathways Contribute to DC Dysfunction in Lupus
por: Manni, Michela, et al.
Publicado: (2015)

Interstitial lung disease in STING-associated vasculopathy with onset in infancy (SAVI): preliminary genotype-phenotype correlation
por: Malle, L, et al.
Publicado: (2015)

Case report: JAK1/2 inhibition with baricitinib in the treatment of STING-associated vasculopathy with onset in infancy
por: Wu, Jianqiang, et al.
Publicado: (2023)

IRF1 Downregulation by Ras/MEK Is Independent of Translational Control of IRF1 mRNA
por: Komatsu, Yumiko, et al.
Publicado: (2016)

T cell fate following Salmonella infection is determined by a STING-IRF1 signaling axis in mice
por: Park, Sung-Moo, et al.
Publicado: (2019)

The herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐κB signaling and STING's dual role during MCMV infection
por: Stempel, Markus, et al.
Publicado: (2019)

mtDNA-STING Axis Mediates Microglial Polarization via IRF3/NF-κB Signaling After Ischemic Stroke
por: Kong, Lingqi, et al.
Publicado: (2022)

STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3
por: Li, Ning, et al.
Publicado: (2019)

SGLT2 inhibitor activates the STING/IRF3/IFN-β pathway and induces immune infiltration in osteosarcoma
por: Wu, Wei, et al.
Publicado: (2022)

Expression of a constitutively active human STING mutant in hematopoietic cells produces an Ifnar1-dependent vasculopathy in mice
por: Martin, Gary R, et al.
Publicado: (2019)

Phenotypic spectrum in recessive STING-associated vasculopathy with onset in infancy: Four novel cases and analysis of previously reported cases
por: Wan, Rensheng, et al.
Publicado: (2022)

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling
por: Hansen, Anne Louise, et al.
Publicado: (2018)

Induction of PLSCR1 in a STING/IRF3-Dependent Manner upon Vector Transfection in Ovarian Epithelial Cells
por: Kodigepalli, Karthik M., et al.
Publicado: (2015)

Impacts of the STING‐IFNAR1‐STAT1‐IRF1 pathway on the cellular immune reaction induced by fractionated irradiation
por: Du, Junyan, et al.
Publicado: (2022)

cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection
por: Li, Qiang, et al.
Publicado: (2019)

The cGAS/STING–TBK1–IRF Regulatory Axis Orchestrates a Primitive Interferon-Like Antiviral Mechanism in Oyster
por: Qiao, Xue, et al.
Publicado: (2021)

Staphylococcus aureus planktonic but not biofilm environment induces an IFN-β macrophage immune response via the STING/IRF3 pathway
por: Seebach, Elisabeth, et al.
Publicado: (2023)

MyD88 and STING Signaling Pathways Are Required for IRF3-Mediated IFN-β Induction in Response to Brucella abortus Infection
por: de Almeida, Leonardo A., et al.
Publicado: (2011)

Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response
por: Li, Tiejun, et al.
Publicado: (2016)

Chicken DDX3X Activates IFN-β via the chSTING-chIRF7-IFN-β Signaling Axis
por: Niu, Qiaona, et al.
Publicado: (2019)

TRIM21 Aggravates Herpes Simplex Virus Epithelial Keratitis by Attenuating STING-IRF3-Mediated Type I Interferon Signaling
por: Tan, Tianchang, et al.
Publicado: (2020)

Role of Transcranial Doppler in the Evaluation of Vasculopathy in Tuberculous Meningitis
por: Tai, Mei-Ling Sharon, et al.
Publicado: (2016)

APOL1-Associated Collapsing Focal Segmental Glomerulosclerosis in a Patient With Stimulator of Interferon Genes (STING)-Associated Vasculopathy With Onset in Infancy (SAVI)
por: Abid, Qassim, et al.
Publicado: (2020)

Treatment of STING-associated vasculopathy with onset in infancy in patients carrying a novel mutation in the TMEM173 gene with the JAK3-inhibitor tofacitinib
por: Tokgun, Pervin Elvan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_diirqhppha15fc3tc5d3red3qu