Cargando…

B cell–derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity

Recent studies have identified critical roles for B cells in triggering autoimmune germinal centers (GCs) in systemic lupus erythematosus (SLE) and other disorders. The mechanisms whereby B cells facilitate loss of T cell tolerance, however, remain incompletely defined. Activated B cells produce int...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arkatkar, Tanvi, Du, Samuel W., Jacobs, Holly M., Dam, Elizabeth M., Hou, Baidong, Buckner, Jane H., Rawlings, David J., Jackson, Shaun W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679179/ https://www.ncbi.nlm.nih.gov/pubmed/28899868 http://dx.doi.org/10.1084/jem.20170580

Ejemplares similares

B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6
por: Jackson, Shaun W., et al.
Publicado: (2016)

The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets
por: Gorman, Jacquelyn A., et al.
Publicado: (2019)

Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation
por: Wray-Dutra, Michelle N., et al.
Publicado: (2018)

IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity
por: Domeier, Phillip P., et al.
Publicado: (2016)

The A946T variant IFIH1 RNA sensor mediates an interferon program that limits viral infection but increases the risk for autoimmunity
por: Gorman, Jacquelyn A., et al.
Publicado: (2017)

PTEN-Regulated AID Transcription in Germinal Center B Cells Is Essential for the Class-Switch Recombination and IgG Antibody Responses
por: Wang, Jing, et al.
Publicado: (2018)

Down syndrome: insights into autoimmune mechanisms
por: Khor, Bernard, et al.
Publicado: (2023)

Artesunate Abolishes Germinal Center B Cells and Inhibits Autoimmune Arthritis
por: Hou, Lifei, et al.
Publicado: (2014)

Targeting autoreactive germinal centers to curb autoimmunity
por: Degn, Søren E., et al.
Publicado: (2017)

An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells
por: Long, S Alice, et al.
Publicado: (2010)

Genetic basis of defects in immune tolerance underlying the development of autoimmunity
por: Hocking, Anne M., et al.
Publicado: (2022)

Altered Germinal-Center Metabolism in B Cells in Autoimmunity
por: Shiraz, Ashton K., et al.
Publicado: (2022)

Trypanosoma cruzi trans-sialidase initiates an ROR-γt–AHR-independent program leading to IL-17 production by activated B cells
por: Bermejo, Daniela A, et al.
Publicado: (2013)

The Transcriptional Regulation of Germinal Center Formation
por: Song, Shuang, et al.
Publicado: (2018)

Data regarding transplant induced germinal center humoral autoimmunity
por: Qureshi, M. Saeed, et al.
Publicado: (2018)

Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ
por: Beccaria, Cristian Gabriel, et al.
Publicado: (2018)

Increased Binding of Specificity Protein 1 to the IL21R Promoter in B Cells Results in Enhanced B Cell Responses in Rheumatoid Arthritis
por: Dam, Elizabeth M., et al.
Publicado: (2018)

MYC is essential for the formation and maintenance of germinal centers
por: Calado, Dinis Pedro, et al.
Publicado: (2012)

Corrigendum: Increased Binding of Specificity Protein 1 to the IL21R Promoter in B Cells Results in Enhanced B Cell Responses in Rheumatoid Arthritis
por: Dam, Elizabeth M., et al.
Publicado: (2019)

Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity
por: Zhang, Heng, et al.
Publicado: (2019)

Regulation of the germinal center response by nuclear receptors and implications for autoimmune diseases
por: Olson, William J., et al.
Publicado: (2020)

Generation of a cost-effective cell line for support of high-throughput isolation of primary human B cells and monoclonal neutralizing antibodies
por: Whaley, Rachael E., et al.
Publicado: (2021)

Dyslipidemia promotes germinal center reactions via IL-27
por: Ryu, Heeju, et al.
Publicado: (2018)

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors
por: Ishigaki, Kazuyoshi, et al.
Publicado: (2022)

Invasion of spontaneous germinal centers by naive B cells is rapid and persistent
por: van den Broek, T., et al.
Publicado: (2023)

Anti-IL-6 Receptor Antibody Inhibits Spontaneous Pain at the Pre-onset of Experimental Autoimmune Encephalomyelitis in Mice
por: Serizawa, Kenichi, et al.
Publicado: (2019)

Multiple Autoimmune-Associated Variants Confer Decreased IL-2R Signaling in CD4(+)CD25(hi) T Cells of Type 1 Diabetic and Multiple Sclerosis Patients
por: Cerosaletti, Karen, et al.
Publicado: (2013)

Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing ER stress
por: Al Qureshah, Fahd, et al.
Publicado: (2021)

On the Germinal Matter of the Blood, with Remarks upon the Formation of Fibrin
por: Beale, Lionel S.
Publicado: (1866)

Mice expressing HLA-DQ6α8β transgenes develop polychondritis spontaneously
por: Lamoureux, Jennifer L, et al.
Publicado: (2006)

Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes
por: Johnson, Matthew B., et al.
Publicado: (2019)

Autoimmune Theories of Chronic Spontaneous Urticaria
por: Bracken, Sonali J., et al.
Publicado: (2019)

WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity
por: Becker-Herman, Shirly, et al.
Publicado: (2011)

Autoimmune Diseases Are Linked to Type IIb Autoimmune Chronic Spontaneous Urticaria
por: Kolkhir, Pavel, et al.
Publicado: (2021)

Clinical Implications of Excessive Neutrophil Extracellular Trap Formation in Renal Autoimmune Diseases
por: van Dam, Laura S., et al.
Publicado: (2018)

Cytoskeleton in the Parasitic Plant Cuscuta During Germination and Prehaustorium Formation
por: Kaštier, Peter, et al.
Publicado: (2018)

IL-37 restrains autoimmune diseases
por: Ye, Liang, et al.
Publicado: (2015)

IL-6 in inflammation, autoimmunity and cancer
por: Hirano, Toshio
Publicado: (2020)

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
por: Batten, Marcel, et al.
Publicado: (2010)

Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells
por: Hale, Malika, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_1cve0ilerajuuipgp9j3l9fost