Emodin reverses leukemia multidrug resistance by competitive inhibition and downregulation of P-glycoprotein

Development of multidrug resistance (MDR) is a continuous clinical challenge partially due to the overexpression of P-glycoprotein (P-gp) for chronic myelogenous leukemia (CML) patients. Herein, we evaluated the inhibitory potency of emodin, a natural anthraquinone derivative isolated from Rheum pal...

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Detalles Bibliográficos
Autores principales: Min, Hongping, Niu, Miaomiao, Zhang, Weilin, Yan, Jia, Li, Jiachang, Tan, Xiying, Li, Bo, Su, Mengxiang, Di, Bin, Yan, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679605/
https://www.ncbi.nlm.nih.gov/pubmed/29121121
http://dx.doi.org/10.1371/journal.pone.0187971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679605/
https://www.ncbi.nlm.nih.gov/pubmed/29121121
http://dx.doi.org/10.1371/journal.pone.0187971

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