The phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction–dependent manner

The small GTPases of the Rho family comprising RhoA, Rac1 and Cdc42 function as molecular switches controlling several essential biochemical pathways in eukaryotic cells. Their activity is cycling between an active GTP-bound and an inactive GDP-bound conformation. The exchange of GDP to GTP is catal...

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Detalles Bibliográficos
Autores principales: Keller-Pinter, Aniko, Ughy, Bettina, Domoki, Monika, Pettko-Szandtner, Aladar, Letoha, Tamas, Tovari, Jozsef, Timar, Jozsef, Szilak, Laszlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679609/
https://www.ncbi.nlm.nih.gov/pubmed/29121646
http://dx.doi.org/10.1371/journal.pone.0187094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679609/
https://www.ncbi.nlm.nih.gov/pubmed/29121646
http://dx.doi.org/10.1371/journal.pone.0187094

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