Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway

Busulphan (Bu) is an alkylating agent used in the conditioning regimen prior to hematopoietic stem cell transplantation (HSCT). Bu is extensively metabolized in the liver via conjugations with glutathione to form the intermediate metabolite (sulfonium ion) which subsequently is degraded to tetrahydr...

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Detalles Bibliográficos
Autores principales: El-Serafi, Ibrahim, Terelius, Ylva, Abedi-Valugerdi, Manuchehr, Naughton, Seán, Saghafian, Maryam, Moshfegh, Ali, Mattsson, Jonas, Potácová, Zuzana, Hassan, Moustapha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679629/
https://www.ncbi.nlm.nih.gov/pubmed/29121650
http://dx.doi.org/10.1371/journal.pone.0187294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679629/
https://www.ncbi.nlm.nih.gov/pubmed/29121650
http://dx.doi.org/10.1371/journal.pone.0187294

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