Cargando…

Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway

Busulphan (Bu) is an alkylating agent used in the conditioning regimen prior to hematopoietic stem cell transplantation (HSCT). Bu is extensively metabolized in the liver via conjugations with glutathione to form the intermediate metabolite (sulfonium ion) which subsequently is degraded to tetrahydr...

Descripción completa

Detalles Bibliográficos
Autores principales:	El-Serafi, Ibrahim, Terelius, Ylva, Abedi-Valugerdi, Manuchehr, Naughton, Seán, Saghafian, Maryam, Moshfegh, Ali, Mattsson, Jonas, Potácová, Zuzana, Hassan, Moustapha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679629/ https://www.ncbi.nlm.nih.gov/pubmed/29121650 http://dx.doi.org/10.1371/journal.pone.0187294

Ejemplares similares

Correction: Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
Publicado: (2017)

Cyclophosphamide Alters the Gene Expression Profile in Patients Treated with High Doses Prior to Stem Cell Transplantation
por: El-Serafi, Ibrahim, et al.
Publicado: (2014)

Biodistribution of biodegradable polymeric nano-carriers loaded with busulphan and designed for multimodal imaging
por: Asem, Heba, et al.
Publicado: (2016)

Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians
por: Dolan, Ciara, et al.
Publicado: (2005)

Flavin-Containing Monooxygenase 3 (FMO3) Is Critical for Dioxin-Induced Reorganization of the Gut Microbiome and Host Insulin Sensitivity
por: Massey, William, et al.
Publicado: (2022)

Cytochrome P450 Oxidoreductase Influences CYP2B6 Activity in Cyclophosphamide Bioactivation
por: El-Serafi, Ibrahim, et al.
Publicado: (2015)

Analysis of six novel flavin-containing monooxygenase 3 (FMO3) gene variants found in a Japanese population suffering from trimethylaminuria
por: Shimizu, Makiko, et al.
Publicado: (2015)

Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease
por: Fennema, Diede, et al.
Publicado: (2016)

The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing
por: Gonzalez Malagon, Sandra G., et al.
Publicado: (2015)

Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria
por: Scott, Flora, et al.
Publicado: (2017)

Metabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice
por: Varshavi, Dorsa, et al.
Publicado: (2018)

COL-3-Induced Molecular and Ultrastructural Alterations in K562 Cells
por: Fares, Mona, et al.
Publicado: (2022)

Metabolomic and transcriptomic analyses of Fmo5(-/)(- )mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism
por: Phillips, Ian R., et al.
Publicado: (2023)

The Role of Programmed Cell Death Ligand-1 (PD-L1/CD274) in the Development of Graft versus Host Disease
por: Al-Chaqmaqchi, Heevy, et al.
Publicado: (2013)

Novel flavin-containing monooxygenase protein FMO1 interacts with CAT2 to negatively regulate drought tolerance through ROS homeostasis and ABA signaling pathway in tomato
por: Wang, Lulu, et al.
Publicado: (2023)

Chopping and Changing: the Evolution of the Flavin-dependent Monooxygenases
por: Mascotti, Maria Laura, et al.
Publicado: (2016)

Evolution of enzyme functionality in the flavin-containing monooxygenases
por: Bailleul, Gautier, et al.
Publicado: (2023)

The Origin and Evolution of Baeyer—Villiger Monooxygenases (BVMOs): An Ancestral Family of Flavin Monooxygenases
por: Mascotti, Maria Laura, et al.
Publicado: (2015)

Essential thrombocythemia: Busulphan revisited
por: Koduri, Prasad R.
Publicado: (2016)

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis
por: Miao, Ji, et al.
Publicado: (2015)

Effect of Human Flavin-Containing Monooxygenase 3 Polymorphism on the Metabolism of Aurora Kinase Inhibitors
por: Catucci, Gianluca, et al.
Publicado: (2013)

Busulphan in the Treatment of Chronic Granulocytic Leukaemia
por: Bridges, J. M., et al.
Publicado: (1961)

Flavin-Containing Monooxygenases Are Conserved Regulators of Stress Resistance and Metabolism
por: Huang, Shijiao, et al.
Publicado: (2021)

QM/MM Modeling of the Flavin Functionalization in the RutA Monooxygenase
por: Grigorenko, Bella, et al.
Publicado: (2023)

Triepoxide formation by a flavin-dependent monooxygenase in monensin biosynthesis
por: Wang, Qian, et al.
Publicado: (2023)

Structural and kinetic insights into flavin-containing monooxygenase and calponin-homology domains in human MICAL3
por: Kim, Junsoo, et al.
Publicado: (2020)

Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning
por: Sadeghi, Behnam, et al.
Publicado: (2010)

Busulphan-Cyclophosphamide Cause Endothelial Injury, Remodeling of Resistance Arteries and Enhanced Expression of Endothelial Nitric Oxide Synthase
por: Al-Hashmi, Sulaiman, et al.
Publicado: (2012)

Two Novel Flavin-Containing Monooxygenases Involved in Biosynthesis of Aliphatic Glucosinolates
por: Kong, Wenwen, et al.
Publicado: (2016)

Flavin Conjugated Polydopamine Nanoparticles Displaying Light-Driven Monooxygenase Activity
por: Crocker, Leander, et al.
Publicado: (2019)

Use of Flavin-Containing Monooxygenases for Conversion of Trimethylamine in Salmon Protein Hydrolysates
por: Goris, Marianne, et al.
Publicado: (2020)

Metabolic Regulation of Longevity by One-Carbon Metabolism and Flavin-Containing Monooxygenase
por: Choi, Christopher, et al.
Publicado: (2020)

Properties and Mechanisms of Flavin-Dependent Monooxygenases and Their Applications in Natural Product Synthesis
por: Deng, Yaming, et al.
Publicado: (2022)

Engineered Bacterial Flavin‐Dependent Monooxygenases for the Regiospecific Hydroxylation of Polycyclic Phenols
por: Herrmann, Susann, et al.
Publicado: (2022)

A flavin-monooxygenase catalyzing oxepinone formation and the complete biosynthesis of vibralactone
por: Feng, Ke-Na, et al.
Publicado: (2023)

Upregulation of flavin-containing monooxygenase 3 mimics calorie restriction to retard liver aging by inducing autophagy
por: Guo, Donghao, et al.
Publicado: (2020)

miR-1266-5p and miR-185-5p Promote Cell Apoptosis in Human Prostate Cancer Cell Lines
por: Ostadrahimi, Shiva, et al.
Publicado: (2018)

C. elegans flavin-containing monooxygenase-4 is essential for osmoregulation in hypotonic stress
por: Hirani, Nisha, et al.
Publicado: (2016)

C. elegans flavin-containing monooxygenase-4 is essential for osmoregulation in hypotonic stress
por: Hirani, Nisha, et al.
Publicado: (2016)

Oxidative dehalogenation and denitration by a flavin-dependent monooxygenase is controlled by substrate deprotonation
por: Pimviriyakul, Panu, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_2mfjtctidlugpv5gmc5h5p2pvl