A dominant-negative mutant inhibits multiple prion variants through a common mechanism

Prions adopt alternative, self-replicating protein conformations and thereby determine novel phenotypes that are often irreversible. Nevertheless, dominant-negative prion mutants can revert phenotypes associated with some conformations. These observations suggest that, while intervention is possible...

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Detalles Bibliográficos
Autores principales: Pei, Fen, DiSalvo, Susanne, Sindi, Suzanne S., Serio, Tricia R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679637/
https://www.ncbi.nlm.nih.gov/pubmed/29084237
http://dx.doi.org/10.1371/journal.pgen.1007085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679637/
https://www.ncbi.nlm.nih.gov/pubmed/29084237
http://dx.doi.org/10.1371/journal.pgen.1007085

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