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A dominant-negative mutant inhibits multiple prion variants through a common mechanism
Prions adopt alternative, self-replicating protein conformations and thereby determine novel phenotypes that are often irreversible. Nevertheless, dominant-negative prion mutants can revert phenotypes associated with some conformations. These observations suggest that, while intervention is possible...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679637/ https://www.ncbi.nlm.nih.gov/pubmed/29084237 http://dx.doi.org/10.1371/journal.pgen.1007085 |