Genetic and pharmacological antagonism of NK(1) receptor prevents opiate abuse potential

Development of an efficacious, non-addicting analgesic has been challenging. Discovery of novel mechanisms underlying addiction may present a solution. Here, we target the neurokinin system, which is involved in both pain and addiction. Morphine exerts its rewarding actions, at least in part, by inh...

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Detalles Bibliográficos
Autores principales: Sandweiss, Alexander J., McIntosh, Mary I., Moutal, Aubin, Davidson-Knapp, Rachel, Hu, Jackie, Giri, Aswini K., Yamamoto, Takashi, Hruby, Victor J., Khanna, Rajesh, Largent-Milnes, Tally M., Vanderah, Todd W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680162/
https://www.ncbi.nlm.nih.gov/pubmed/28485408
http://dx.doi.org/10.1038/mp.2017.102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680162/
https://www.ncbi.nlm.nih.gov/pubmed/28485408
http://dx.doi.org/10.1038/mp.2017.102

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