Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein

Kinesin microtubule motor proteins play essential roles in division, including attaching chromosomes to spindles and crosslinking microtubules for spindle assembly. Human kinesin-14 KIFC1 is unique in that cancer cells with amplified centrosomes are dependent on the motor for viable division because...

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Detalles Bibliográficos
Autores principales: Park, Hee-Won, Ma, Zhujun, Zhu, Haizhong, Jiang, Shimin, Robinson, Robert C., Endow, Sharyn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680195/
https://www.ncbi.nlm.nih.gov/pubmed/29123223
http://dx.doi.org/10.1038/s41598-017-14754-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680195/
https://www.ncbi.nlm.nih.gov/pubmed/29123223
http://dx.doi.org/10.1038/s41598-017-14754-6

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