Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1

Amino acid-dependent activation of the mechanistic target of rapamycin complex 1 (mTORC1) is mediated by Rag GTPases, which are recruited to the lysosome by the Ragulator complex consisting of p18, MP1, p14, HBXIP and C7orf59; however, the molecular mechanism is elusive. Here, we report the crystal...

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Detalles Bibliográficos
Autores principales: Zhang, Tianlong, Wang, Rong, Wang, Zhijing, Wang, Xiangxiang, Wang, Fang, Ding, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680233/
https://www.ncbi.nlm.nih.gov/pubmed/29123114
http://dx.doi.org/10.1038/s41467-017-01567-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680233/
https://www.ncbi.nlm.nih.gov/pubmed/29123114
http://dx.doi.org/10.1038/s41467-017-01567-4

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