Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease

Cerebrovascular changes occur in Alzheimer’s disease (AD). Using in vivo phage display, we searched for molecular markers of the neurovascular unit, including endothelial cells and astrocytes, in mouse models of AD. We identified a cyclic peptide, CDAGRKQKC (DAG), that accumulates in the hippocampus...

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Detalles Bibliográficos
Autores principales: Mann, Aman P., Scodeller, Pablo, Hussain, Sazid, Braun, Gary B., Mölder, Tarmo, Toome, Kadri, Ambasudhan, Rajesh, Teesalu, Tambet, Lipton, Stuart A., Ruoslahti, Erkki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680235/
https://www.ncbi.nlm.nih.gov/pubmed/29123083
http://dx.doi.org/10.1038/s41467-017-01096-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680235/
https://www.ncbi.nlm.nih.gov/pubmed/29123083
http://dx.doi.org/10.1038/s41467-017-01096-0

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