Structural insights into DNA cleavage activation of CRISPR-Cas9 system

CRISPR-Cas9 technology has been widely used for genome engineering. Its RNA-guided endonuclease Cas9 binds specifically to target DNA and then cleaves the two DNA strands with HNH and RuvC nuclease domains. However, structural information regarding the DNA cleavage-activating state of two nuclease d...

Descripción completa

Detalles Bibliográficos
Autores principales: Huai, Cong, Li, Gan, Yao, Ruijie, Zhang, Yingyi, Cao, Mi, Kong, Liangliang, Jia, Chenqiang, Yuan, Hui, Chen, Hongyan, Lu, Daru, Huang, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680257/
https://www.ncbi.nlm.nih.gov/pubmed/29123204
http://dx.doi.org/10.1038/s41467-017-01496-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680257/
https://www.ncbi.nlm.nih.gov/pubmed/29123204
http://dx.doi.org/10.1038/s41467-017-01496-2

Ejemplares similares