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Structural insights into DNA cleavage activation of CRISPR-Cas9 system

CRISPR-Cas9 technology has been widely used for genome engineering. Its RNA-guided endonuclease Cas9 binds specifically to target DNA and then cleaves the two DNA strands with HNH and RuvC nuclease domains. However, structural information regarding the DNA cleavage-activating state of two nuclease d...

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Detalles Bibliográficos
Autores principales:	Huai, Cong, Li, Gan, Yao, Ruijie, Zhang, Yingyi, Cao, Mi, Kong, Liangliang, Jia, Chenqiang, Yuan, Hui, Chen, Hongyan, Lu, Daru, Huang, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680257/ https://www.ncbi.nlm.nih.gov/pubmed/29123204 http://dx.doi.org/10.1038/s41467-017-01496-2

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