ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1

ATR kinase activity slows replication forks and prevents origin firing in damaged cells. Here we describe proteomic analyses that identified mechanisms through which ATR kinase inhibitors induce unscheduled origin firing in undamaged cells. ATR-Chk1 inhibitor-induced origin firing is mediated by Cdc...

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Detalles Bibliográficos
Autores principales: Moiseeva, Tatiana, Hood, Brian, Schamus, Sandy, O’Connor, Mark J., Conrads, Thomas P., Bakkenist, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680267/
https://www.ncbi.nlm.nih.gov/pubmed/29123096
http://dx.doi.org/10.1038/s41467-017-01401-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680267/
https://www.ncbi.nlm.nih.gov/pubmed/29123096
http://dx.doi.org/10.1038/s41467-017-01401-x

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