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ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1
ATR kinase activity slows replication forks and prevents origin firing in damaged cells. Here we describe proteomic analyses that identified mechanisms through which ATR kinase inhibitors induce unscheduled origin firing in undamaged cells. ATR-Chk1 inhibitor-induced origin firing is mediated by Cdc...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680267/ https://www.ncbi.nlm.nih.gov/pubmed/29123096 http://dx.doi.org/10.1038/s41467-017-01401-x |