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The gene fmt, encoding tRNA(fMet)-formyl transferase, is essential for normal growth of M. bovis, but not for viability

Mycobacterium tuberculosis is a major health threat, necessitating novel drug targets. Protein synthesis in bacteria uses initiator tRNA(i) charged with formylated methionine residue. Deletion of the formylase gene, tRNA(fMet)-formyl transferase (fmt), causes severe growth-retardation in E. coli and...

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Detalles Bibliográficos
Autores principales: Vanunu, Miriam, Lang, Ziv, Barkan, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680289/
https://www.ncbi.nlm.nih.gov/pubmed/29123253
http://dx.doi.org/10.1038/s41598-017-15618-9